SYPL2

Across TCGA patient cohorts, SYPL2 protein abundance is significantly associated with the RNA expression of many other genes, with 1,684 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible SYPL2-associated genes across cancer lineages are RPL37P12, TRIM54, and PAQR7. Each is linked with SYPL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SYPL2-to-partner and partner-to-SYPL2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SYPL2 versus RPL37P12 in LSCC, with a Pearson correlation of -0.75.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYPL2→partner) and Y-score (partner→SYPL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RPL37P12 →	-0.993	-0.728	.005	.007	3	2
CCRCC	TRIM54 →	+2.510	+0.934	.002	.006	3	2
CCRCC	PAQR7 →	+0.728	+1.030	.001	<.001	3	2
HNSC	LMOD3 →	+1.983	+1.990	<.001	<.001	3	2
CCRCC	SORBS1 →	+0.976	+0.909	.004	.001	3	2
LSCC	LRP5L →	-0.992	-0.653	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,684 associations by consensus.

SYPL2 vs RPL37P12 — LSCC

Explore this scatter interactively →