SYPL2

Across TCGA patient cohorts, SYPL2 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYPL2-associated genes across cancer lineages are Rab25, eIF4E, and FASN. Each is linked with SYPL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SYPL2-to-partner and partner-to-SYPL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rab25 grouped by SYPL2-low versus SYPL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYPL2→partner) and Y-score (partner→SYPL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rab25 →	-0.298	-1.807	.029	.027	3	2
UCEC	eIF4E →	+0.211	+3.183	.015	.009	3	1
UCEC	FASN →	+0.407	+3.000	.012	.001	3	1
UCEC	FoxM1 →	+0.227	+1.807	.033	.027	3	1
UCEC	FOXO3a_pS318_S321 →	-0.156	-3.584	.002	.002	3	1
UCEC	ACC1 →	+0.324	+1.807	.031	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Rab25 by SYPL2 expression — UCEC

Explore this box plot interactively →