SYPL2

Across TCGA cell cohorts, SYPL2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,094 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SYPL2-associated GO terms across cancer lineages are Cardiac muscle cell action potential, Negative regulation of myoblast fusion, and RNA splicing, via transesterification reactions with bulged adenosine as nucleophile. Each is linked with SYPL2 in more than 9 cancer types. Because this analysis shows association rather than direction, both SYPL2-to-partner and partner-to-SYPL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cardiac muscle cell action potential grouped by SYPL2-low versus SYPL2-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SYPL2→partner) and Y-score (partner→SYPL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Cardiac muscle cell action potential →	-0.126	-0.125	<.001	.002	3	10
CNS	Negative regulation of myoblast fusion →	+0.047	+0.421	.001	.005	3	9
LARGE_INTESTINE	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile →	+0.036	+0.163	.004	.004	3	9
LARGE_INTESTINE	mRNA splicing, via spliceosome →	+0.036	+0.163	.004	.004	3	9
LARGE_INTESTINE	Ventricular cardiac muscle cell action potential →	-0.128	-0.113	<.001	.005	3	8
CNS	Negative regulation of syncytium formation by plasma membrane fusion →	+0.075	+0.829	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,094 associations by consensus.

Cardiac muscle cell action potential by SYPL2 expression — LARGE_INTESTINE

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