SYPL2

Across TCGA cell cohorts, SYPL2 mutation is significantly associated with the mutation status of many other genes, with 1,290 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SYPL2-associated genes across cancer lineages are PPFIA3, CHGA, and TRIM23. Each is linked with SYPL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SYPL2-to-partner and partner-to-SYPL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPFIA3 grouped by SYPL2-low versus SYPL2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYPL2→partner) and Y-score (partner→SYPL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PPFIA3 →	+2.514	+3.058	.002	.002	1	3
LARGE_INTESTINE	CHGA →	+3.584	+3.007	.008	.008	1	3
LARGE_INTESTINE	TRIM23 →	+3.415	+3.215	.002	.002	1	3
SKIN	ERBB3 →	+4.239	+5.053	.007	.007	1	2
SKIN	UGT2B7 →	+4.239	+5.053	.007	.007	1	2
SKIN	AGMO →	+5.824	+5.824	.002	.002	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,290 associations by consensus.

PPFIA3 by SYPL2 expression — LARGE_INTESTINE

Explore this box plot interactively →