SYPL2

Across TCGA cell cohorts, SYPL2 mutation is significantly associated with the drug of many other genes, with 39 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SYPL2-associated genes across cancer lineages are Staurosporine, Nutlin-3a (-), and FS112. Each is linked with SYPL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SYPL2-to-partner and partner-to-SYPL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Staurosporine grouped by SYPL2-low versus SYPL2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYPL2→partner) and Y-score (partner→SYPL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Staurosporine →	+0.551	+2.868	.012	.022	3	1
LARGE_INTESTINE	Nutlin-3a (-) →	+0.897	+2.868	.008	.022	3	1
LARGE_INTESTINE	FS112 →	+0.732	+2.786	.001	.037	3	1
LARGE_INTESTINE	FY012 →	+0.431	+2.649	.037	.046	3	1
LARGE_INTESTINE	Fulvestrant →	+0.349	+2.871	.025	.021	3	1
LARGE_INTESTINE	Doxorubicin →	+0.589	+2.649	.028	.046	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Staurosporine by SYPL2 expression — LARGE_INTESTINE

Explore this box plot interactively →