SYP

Across TCGA pan-cancer cohorts, SYP Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SYP data layer compared with 24 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher SYP Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SYP expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

LUSC, UCEC, and LIHC are the cancer types where SYP Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	All	0.138	0.776	<.001	12	view →
UCEC	DFS	Median	All	1.000	0.828	.012	10	view →
LIHC	OS	Median	All	0.255	0.773	.012	9	view →
SARC	OS	Median	All	0.144	0.745	.001	6	view →
GBM	OS	Median	All	0.089	0.413	.015	6	view →
HNSC	OS	Median	All	0.192	0.685	.045	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SYP–LUSC (OS)

Open the LUSC breakdown →