SYNRG

Across TCGA pan-cancer cohorts, SYNRG Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SYNRG data layer compared with 27 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SYNRG Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated SYNRG expression acts as an unfavorable survival marker, although some lineages such as UCEC and MESO show a favorable association.

UCEC, LUAD, and MESO are the cancer types where SYNRG Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.963	0.823	.004	22	view →
LUAD	DFS	Median	II,III,IV	0.178	0.721	.008	6	view →
MESO	DFS	Median	All	1.000	0.179	.041	3	view →
LGG	DFS	Median	All	0.237	0.826	.002	3	view →
LIHC	OS	Median	All	0.352	0.781	<.001	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SYNRG–UCEC (DFS)

Open the UCEC breakdown →