SYNRG

Across TCGA patient cohorts, SYNRG mutation is significantly associated with the RNA expression of many other genes, with 6,982 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYNRG-associated genes across cancer lineages are HSBP1L1, AUNIP, and FAM136A. Each is linked with SYNRG in more than 3 cancer types. Because this analysis shows association rather than direction, both SYNRG-to-partner and partner-to-SYNRG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSBP1L1 grouped by SYNRG-low versus SYNRG-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNRG→partner) and Y-score (partner→SYNRG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	HSBP1L1 →	+0.601	+3.459	<.001	.005	3	4
UCEC	AUNIP →	+0.757	+2.285	<.001	<.001	3	4
COAD	FAM136A →	+0.461	+3.510	<.001	.002	3	4
UCEC	EXOSC2 →	+0.385	+1.919	<.001	<.001	3	4
UCEC	BUB3 →	+0.529	+1.710	<.001	<.001	3	4
UCEC	RANBP1 →	+0.567	+2.078	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,982 associations by consensus.

HSBP1L1 by SYNRG expression — COAD

Explore this box plot interactively →