SYNRG

Across TCGA patient cohorts, SYNRG mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYNRG-associated genes across cancer lineages are NF2, ASNS, and GAPDH. Each is linked with SYNRG in more than 3 cancer types. Because this analysis shows association rather than direction, both SYNRG-to-partner and partner-to-SYNRG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NF2 grouped by SYNRG-low versus SYNRG-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNRG→partner) and Y-score (partner→SYNRG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	NF2 →	+0.329	+3.169	.020	.019	3	4
COAD	ASNS →	+0.698	+3.467	<.001	.002	3	3
UCEC	GAPDH →	+0.318	+1.415	.039	.040	3	3
UCEC	PCNA →	+0.223	+1.954	<.001	<.001	3	3
UCEC	ATM →	-0.557	-1.736	<.001	<.001	3	3
COAD	EGFR_pY1068 →	-0.384	-3.000	.009	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

NF2 by SYNRG expression — SKCM

Explore this box plot interactively →