SYNRG

Across TCGA cell cohorts, SYNRG mutation is significantly associated with the RNA expression of many other genes, with 401 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SYNRG-associated genes across cancer lineages are ARR3, ARHGEF15, and TMIGD1. Each is linked with SYNRG in more than 1 cancer types. Because this analysis shows association rather than direction, both SYNRG-to-partner and partner-to-SYNRG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ARR3 grouped by SYNRG-low versus SYNRG-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNRG→partner) and Y-score (partner→SYNRG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ARR3 →	+0.195	+3.310	.001	.009	3	2
BLOOD_Lymphoma	ARHGEF15 →	+0.053	+3.165	<.001	.004	3	2
LUNG_NSCLC_LUSC	TMIGD1 →	+0.023	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	MDFIC2 →	+0.026	+4.643	<.001	.008	3	1
BLOOD_Leukemia	SLC32A1 →	+0.603	+3.771	<.001	.004	3	1
BLOOD_Leukemia	GML →	+0.080	+3.567	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 401 associations by consensus.

ARR3 by SYNRG expression — BLOOD_Lymphoma

Explore this box plot interactively →