SYNPR

Across TCGA patient cohorts, SYNPR mutation is significantly associated with the RNA expression of many other genes, with 2,844 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYNPR-associated genes across cancer lineages are RNU6-373P, FGF7P4, and RNU6-494P. Each is linked with SYNPR in more than 2 cancer types. Because this analysis shows association rather than direction, both SYNPR-to-partner and partner-to-SYNPR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-373P grouped by SYNPR-low versus SYNPR-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNPR→partner) and Y-score (partner→SYNPR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNU6-373P →	+0.476	+5.273	<.001	.006	3	3
BLCA	FGF7P4 →	+0.114	+7.640	<.001	.009	3	3
BRCA	RNU6-494P →	+0.843	+4.766	<.001	.003	3	2
BRCA	MIR3160-1 →	+1.250	+5.064	<.001	.004	3	2
LUAD	MIR5680 →	+0.482	+4.426	.006	.006	3	2
UCEC	ESS2 →	+0.360	+3.010	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,844 associations by consensus.

RNU6-373P by SYNPR expression — LUSC

Explore this box plot interactively →