SYNPR

Across TCGA patient cohorts, SYNPR mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYNPR-associated genes across cancer lineages are Caspase-7-cleavedD198, EGFR_pY1068, and JNK_pT183_Y185. Each is linked with SYNPR in more than 1 cancer types. Because this analysis shows association rather than direction, both SYNPR-to-partner and partner-to-SYNPR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by SYNPR-low versus SYNPR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNPR→partner) and Y-score (partner→SYNPR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.577	+1.894	.009	.030	3	2
UCEC	EGFR_pY1068 →	-0.271	-3.700	.004	.001	3	1
UCEC	JNK_pT183_Y185 →	-0.187	-1.401	.003	.046	3	1
UCEC	Ku80 →	+0.176	+1.778	.046	.008	3	1
UCEC	MEK1 →	+0.438	+2.662	.001	<.001	3	1
UCEC	Myosin-IIa_pS1943 →	+0.164	+1.428	.034	.029	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Caspase-7-cleavedD198 by SYNPR expression — UCEC

Explore this box plot interactively →