SYNPO

Across TCGA cell cohorts, SYNPO RNA expression is significantly associated with the go_rna of many other GO terms, with 5,502 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SYNPO-associated GO terms across cancer lineages are Regulation of plasma membrane repair, Positive regulation of supramolecular fiber organization, and Positive regulation of plasma membrane repair. Each is linked with SYNPO in more than 14 cancer types. Because this analysis shows association rather than direction, both SYNPO-to-partner and partner-to-SYNPO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of plasma membrane repair grouped by SYNPO-low versus SYNPO-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNPO→partner) and Y-score (partner→SYNPO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of plasma membrane repair →	+0.321	+1.674	<.001	<.001	3	15
LUNG_NSCLC_LUSC	Positive regulation of supramolecular fiber organization →	+0.088	+2.049	<.001	<.001	3	14
SOFT_TISSUE	Positive regulation of plasma membrane repair →	+0.242	+1.988	<.001	<.001	3	14
OESOPHAGUS	Positive regulation of canonical NF-kappaB signal transduction →	+0.060	+1.841	<.001	.002	2	15
BONE	Positive regulation of actin filament bundle assembly →	+0.144	+1.867	<.001	<.001	3	13
LUNG_NSCLC_LUSC	Wound healing →	+0.143	+2.952	.003	.002	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,502 associations by consensus.

Regulation of plasma membrane repair by SYNPO expression — BONE

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