SYNPO

Across TCGA cell cohorts, SYNPO mutation is significantly associated with the RNA expression of many other genes, with 52 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SYNPO-associated genes across cancer lineages are OR2M3, NLRP8, and KLHL34. Each is linked with SYNPO in more than 1 cancer types. Because this analysis shows association rather than direction, both SYNPO-to-partner and partner-to-SYNPO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2M3 grouped by SYNPO-low versus SYNPO-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNPO→partner) and Y-score (partner→SYNPO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	OR2M3 →	+0.006	+5.169	<.001	.005	3	2
OESOPHAGUS	NLRP8 →	+0.006	+4.906	<.001	.006	3	1
OESOPHAGUS	KLHL34 →	+0.013	+4.906	<.001	.006	3	1
OESOPHAGUS	CENPVL1 →	+0.246	+4.906	<.001	.006	3	1
OESOPHAGUS	PPIAL4F →	+0.060	+4.906	<.001	.006	3	1
LARGE_INTESTINE	CISD2 →	+0.650	+3.125	.002	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

OR2M3 by SYNPO expression — BREAST

Explore this box plot interactively →