SYNJ2

Across TCGA pan-cancer cohorts, SYNJ2 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SYNJ2 data layer compared with 30 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher SYNJ2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SYNJ2 expression acts as an unfavorable survival marker, although some lineages such as COAD and CCRCC show a favorable association.

COAD, PDAC, and CCRCC are the cancer types where SYNJ2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	1.000	0.918	.012	18	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	18	view →
CCRCC	OS	Tertile	All	1.000	0.798	.003	14	view →
LUAD	OS	Median	III,IV	0.879	0.285	.001	11	view →
LSCC	DFS	Quartile	II,III,IV	0.618	0.906	.009	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SYNJ2–COAD (DFS)

Open the COAD breakdown →