SYNJ2

Across TCGA patient cohorts, SYNJ2 mutation is significantly associated with the RNA expression of many other genes, with 3,421 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYNJ2-associated genes across cancer lineages are RASSF1, FANCA, and RPL23P4. Each is linked with SYNJ2 in more than 3 cancer types. Because this analysis shows association rather than direction, both SYNJ2-to-partner and partner-to-SYNJ2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RASSF1 grouped by SYNJ2-low versus SYNJ2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNJ2→partner) and Y-score (partner→SYNJ2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RASSF1 →	+0.359	+1.616	.004	.003	3	4
UCEC	FANCA →	+0.452	+2.191	<.001	.001	3	4
KIRP	RPL23P4 →	+0.207	+4.967	<.001	.009	3	3
GBM	RNA5SP478 →	+0.453	+5.352	<.001	.005	3	3
UCEC	SAMM50 →	+0.457	+2.168	<.001	<.001	3	3
UCEC	TXN2 →	+0.339	+2.003	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,421 associations by consensus.

RASSF1 by SYNJ2 expression — SKCM

Explore this box plot interactively →