SYNJ2

Across TCGA patient cohorts, SYNJ2 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYNJ2-associated genes across cancer lineages are FoxM1, C-Raf, and INPP4B. Each is linked with SYNJ2 in more than 3 cancer types. Because this analysis shows association rather than direction, both SYNJ2-to-partner and partner-to-SYNJ2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by SYNJ2-low versus SYNJ2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNJ2→partner) and Y-score (partner→SYNJ2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.201	+1.530	.010	.004	3	4
SKCM	C-Raf →	+0.126	+1.754	.017	.047	3	3
COAD	INPP4B →	-0.444	-3.161	.015	.019	3	3
COAD	ASNS →	+0.929	+3.000	<.001	.034	3	3
UCEC	PCNA →	+0.189	+1.530	.003	.004	3	3
UCEC	Cyclin-B1 →	+0.551	+1.754	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

FoxM1 by SYNJ2 expression — UCEC

Explore this box plot interactively →