SYNJ2

Across TCGA cell cohorts, SYNJ2 mutation is significantly associated with the RNA expression of many other genes, with 1,849 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SYNJ2-associated genes across cancer lineages are SLC5A4, OR11H1, and KDELR3. Each is linked with SYNJ2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SYNJ2-to-partner and partner-to-SYNJ2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC5A4 grouped by SYNJ2-low versus SYNJ2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNJ2→partner) and Y-score (partner→SYNJ2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SLC5A4 →	+0.242	+3.760	<.001	.001	3	2
BLOOD_Leukemia	OR11H1 →	+0.055	+3.879	<.001	<.001	3	2
LARGE_INTESTINE	KDELR3 →	+1.088	+3.459	<.001	.001	3	2
LARGE_INTESTINE	METTL4 →	+0.629	+3.459	<.001	<.001	3	2
LARGE_INTESTINE	PHF7 →	+0.799	+2.351	<.001	.001	3	2
LARGE_INTESTINE	BPNT2 →	+0.520	+2.949	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,849 associations by consensus.

SLC5A4 by SYNJ2 expression — BLOOD_Leukemia

Explore this box plot interactively →