SYNJ1

Across TCGA pan-cancer cohorts, SYNJ1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SYNJ1 data layer compared with 20 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SYNJ1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated SYNJ1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, COAD, and HNSC are the cancer types where SYNJ1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	All	0.939	0.743	.004	26	view →
COAD	DFS	Quartile	III,IV	0.768	1.000	.044	12	view →
HNSC	DFS	Tertile	All	0.881	1.000	.001	10	view →
PDAC	DFS	Median	IV	0.934	0.250	.024	10	view →
GBM	DFS	Tertile	All	0.859	0.674	.018	2	view →
UCEC	DFS	Tertile	II,III,IV	0.727	1.000	.044	2	view →
LSCC	OS	Quartile	III,IV	0.970	0.738	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SYNJ1–CCRCC (OS)

Open the CCRCC breakdown →