SYNGR4

Across TCGA patient cohorts, SYNGR4 mutation is significantly associated with the immune_cell of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYNGR4-associated genes across cancer lineages are MPP, Erythrocytes, and Mesangial cells. Each is linked with SYNGR4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SYNGR4-to-partner and partner-to-SYNGR4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MPP grouped by SYNGR4-low versus SYNGR4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNGR4→partner) and Y-score (partner→SYNGR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MPP →	+0.017	+2.233	.039	.045	3	2
UCEC	Erythrocytes →	+0.033	+2.879	.007	.033	3	1
UCEC	Mesangial cells →	-0.054	-3.305	.005	.010	3	1
UCEC	NKT →	-0.129	-2.975	.015	.036	3	1
UCEC	Endothelial cells →	-0.042	-2.991	.028	.036	2	1
UCEC	pDC →	+0.059	+2.815	.015	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

MPP by SYNGR4 expression — COAD

Explore this box plot interactively →