SYNGR4

Across TCGA cell cohorts, SYNGR4 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SYNGR4-associated genes across cancer lineages are SLITRK3, NPY2R, and GSG1L2. Each is linked with SYNGR4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SYNGR4-to-partner and partner-to-SYNGR4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLITRK3 grouped by SYNGR4-low versus SYNGR4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNGR4→partner) and Y-score (partner→SYNGR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SLITRK3 →	+0.372	+3.658	.003	.005	3	1
LARGE_INTESTINE	NPY2R →	+0.004	+3.632	<.001	.003	3	1
LARGE_INTESTINE	GSG1L2 →	+0.013	+4.022	<.001	.006	3	1
LARGE_INTESTINE	KLF18 →	+0.007	+3.345	<.001	.007	3	1
BLOOD_Leukemia	IQCF5 →	+0.124	+5.201	<.001	.006	3	1
BLOOD_Leukemia	CBLN4 →	+0.006	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

SLITRK3 by SYNGR4 expression — LARGE_INTESTINE

Explore this box plot interactively →