SYNGR3

Across TCGA cell cohorts, SYNGR3 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SYNGR3-associated genes across cancer lineages are ADRA1A, INSM2, and VWC2L. Each is linked with SYNGR3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SYNGR3-to-partner and partner-to-SYNGR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADRA1A grouped by SYNGR3-low versus SYNGR3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNGR3→partner) and Y-score (partner→SYNGR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ADRA1A →	+0.184	+3.705	<.001	.007	3	1
BLOOD_Leukemia	INSM2 →	+0.159	+3.769	.003	.008	3	1
BLOOD_Leukemia	VWC2L →	+0.010	+4.339	<.001	.002	3	1
BLOOD_Leukemia	TBPL2 →	+0.134	+4.044	<.001	.004	3	1
BLOOD_Leukemia	MORN5 →	+0.183	+3.855	<.001	.007	3	1
BLOOD_Leukemia	PRR30 →	+0.019	+4.269	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

ADRA1A by SYNGR3 expression — BLOOD_Leukemia

Explore this box plot interactively →