SYNGR3

Across TCGA cell cohorts, SYNGR3 mutation is significantly associated with the mutation status of many other genes, with 2,494 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SYNGR3-associated genes across cancer lineages are PRUNE1, ANAPC1, and RPRD2. Each is linked with SYNGR3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SYNGR3-to-partner and partner-to-SYNGR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRUNE1 grouped by SYNGR3-low versus SYNGR3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNGR3→partner) and Y-score (partner→SYNGR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PRUNE1 →	+5.050	+4.000	.008	.008	1	2
BLOOD_Leukemia	ANAPC1 →	+3.313	+3.430	.005	.005	1	2
BLOOD_Leukemia	RPRD2 →	+3.050	+3.247	.008	.008	1	2
BLOOD_Leukemia	BAP1 →	+3.728	+4.078	<.001	<.001	1	2
BLOOD_Leukemia	MFSD8 →	+5.050	+4.000	.008	.008	1	2
BLOOD_Leukemia	MAP2K1 →	+3.635	+3.635	.003	.003	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,494 associations by consensus.

PRUNE1 by SYNGR3 expression — BLOOD_Leukemia

Explore this box plot interactively →