SYNGR1

Across TCGA patient cohorts, SYNGR1 mutation is significantly associated with the RNA expression of many other genes, with 2,254 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYNGR1-associated genes across cancer lineages are TMEM138, NDRG2, and GPR137B. Each is linked with SYNGR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SYNGR1-to-partner and partner-to-SYNGR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM138 grouped by SYNGR1-low versus SYNGR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNGR1→partner) and Y-score (partner→SYNGR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TMEM138 →	+0.266	+3.595	.003	.001	3	2
UCEC	NDRG2 →	-1.005	-2.159	<.001	.003	3	2
UCEC	GPR137B →	+0.546	+2.606	.008	.005	3	2
SKCM	RAB32 →	+0.961	+3.616	<.001	.001	3	2
SKCM	VSTM2L →	-1.359	-3.540	.005	.003	3	2
SKCM	RN7SL679P →	+0.108	+3.030	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,254 associations by consensus.

TMEM138 by SYNGR1 expression — UCEC

Explore this box plot interactively →