SYNGR1

Across TCGA patient cohorts, SYNGR1 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYNGR1-associated genes across cancer lineages are LKB1, Ku80, and Notch1. Each is linked with SYNGR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SYNGR1-to-partner and partner-to-SYNGR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LKB1 grouped by SYNGR1-low versus SYNGR1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNGR1→partner) and Y-score (partner→SYNGR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	LKB1 →	+0.144	+2.845	.022	.033	3	2
UCEC	Ku80 →	+0.285	+2.335	.003	.003	3	1
UCEC	Notch1 →	+0.121	+1.807	.037	.027	3	1
UCEC	Rab11 →	-0.146	-2.439	.014	.019	3	1
UCEC	YB-1 →	-0.142	-1.780	.029	.027	3	1
UCEC	Caspase-8 →	-0.273	-2.700	.008	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

LKB1 by SYNGR1 expression — SKCM

Explore this box plot interactively →