Across TCGA patient cohorts, SYNGAP1 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,854 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SYNGAP1-associated proteins across cancer lineages are NELFE, MYEF2, and TRIP4. Each is linked with SYNGAP1 in more than 4 cancer types. Because this analysis shows association rather than direction, both SYNGAP1-to-partner and partner-to-SYNGAP1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNGAP1→partner) and Y-score (partner→SYNGAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NELFE →	+0.247	+0.489	<.001	<.001	3	5
LSCC	MYEF2 →	+0.670	+0.452	.001	<.001	3	4
GBM	TRIP4 →	-0.292	-0.473	<.001	.002	3	4
GBM	GATAD2B →	+0.319	+0.495	.001	.002	3	4
GBM	SMC3 →	+0.288	+0.461	.003	.005	3	4
GBM	WDR5 →	+0.291	+0.554	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,854 associations by consensus.

Exploration

SYNGAP1 survival (RNA) · tumor vs normal (RNA) · all SYNGAP1 data types