Across TCGA patient cohorts, SYNGAP1 protein abundance is significantly associated with the RNA expression of many other genes, with 2,566 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SYNGAP1-associated genes across cancer lineages are PRODH, SOX10, and SLC16A8. Each is linked with SYNGAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SYNGAP1-to-partner and partner-to-SYNGAP1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNGAP1→partner) and Y-score (partner→SYNGAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PRODH →	+1.112	+0.507	<.001	<.001	3	1
GBM	SOX10 →	+1.033	+0.447	.002	<.001	3	1
GBM	SLC16A8 →	+0.517	+0.454	.001	<.001	3	1
GBM	SEPTIN3 →	+0.949	+0.559	<.001	<.001	3	1
GBM	RASL10A →	+0.624	+0.439	<.001	<.001	3	1
GBM	NEFH →	+1.229	+0.548	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,566 associations by consensus.

Exploration

SYNGAP1 survival (RNA) · tumor vs normal (RNA) · all SYNGAP1 data types