Across TCGA patient cohorts, SYNGAP1 mutation is significantly associated with the RNA expression of many other genes, with 5,884 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYNGAP1-associated genes across cancer lineages are RNA5SP213, CCL4, and MIR4735. Each is linked with SYNGAP1 in more than 3 cancer types. Because this analysis shows association rather than direction, both SYNGAP1-to-partner and partner-to-SYNGAP1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNGAP1→partner) and Y-score (partner→SYNGAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	RNA5SP213 →	+0.419	+5.366	<.001	.005	3	4
UCEC	CCL4 →	+0.942	+1.928	<.001	<.001	3	3
STAD	MIR4735 →	+0.703	+5.366	<.001	.005	3	3
HNSC	RNA5SP192 →	+0.264	+5.023	<.001	.003	3	3
READ	MIR6870 →	+0.881	+4.280	<.001	.007	3	3
UCEC	IFI30 →	+0.381	+1.917	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,884 associations by consensus.

Exploration

SYNGAP1 survival (RNA) · tumor vs normal (RNA) · all SYNGAP1 data types