SYNGAP1

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, SYNGAP1 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYNGAP1-associated genes across cancer lineages are eEF2, FoxM1, and MAPK_pT202_Y204. Each is linked with SYNGAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SYNGAP1-to-partner and partner-to-SYNGAP1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNGAP1→partner) and Y-score (partner→SYNGAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECeEF2 →+0.293+1.353.009.01532
UCECFoxM1 →+0.185+1.353.023.01532
UCECMAPK_pT202_Y204 →-0.361-1.847.014.00732
UCECp38-MAPK_pT180_Y182 →-0.491-2.321<.001<.00132
UCECShc_pY317 →-0.216-3.999<.001<.00132
UCECTFRC →+0.490+2.169.003.00332
Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

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