Across TCGA cell cohorts, SYNGAP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,367 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SYNGAP1-associated GO terms across cancer lineages are Subtelomeric heterochromatin formation, Negative regulation of myoblast fusion, and Negative regulation of syncytium formation by plasma membrane fusion. Each is linked with SYNGAP1 in more than 16 cancer types. Because this analysis shows association rather than direction, both SYNGAP1-to-partner and partner-to-SYNGAP1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNGAP1→partner) and Y-score (partner→SYNGAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Subtelomeric heterochromatin formation →	+0.131	+0.982	<.001	<.001	3	17
OESOPHAGUS	Negative regulation of myoblast fusion →	+0.140	+0.980	<.001	<.001	3	17
OESOPHAGUS	Negative regulation of syncytium formation by plasma membrane fusion →	+0.139	+0.980	<.001	<.001	3	17
BONE	Microtubule nucleation →	+0.134	+1.751	<.001	<.001	3	16
LARGE_INTESTINE	Calcium-independent cell-matrix adhesion →	+0.251	+1.433	<.001	<.001	3	16
BONE	Negative regulation of gene expression, epigenetic →	+0.096	+1.666	.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,367 associations by consensus.

Exploration

SYNGAP1 survival (RNA) · tumor vs normal (RNA) · all SYNGAP1 data types