Across TCGA cell cohorts, SYNGAP1 mutation is significantly associated with the RNA expression of many other genes, with 381 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SYNGAP1-associated genes across cancer lineages are MTRNR2L6, CPLX4, and NUP58. Each is linked with SYNGAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SYNGAP1-to-partner and partner-to-SYNGAP1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNGAP1→partner) and Y-score (partner→SYNGAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	MTRNR2L6 →	+0.173	+5.357	<.001	.003	3	2
BLOOD_Lymphoma	CPLX4 →	+0.367	+3.762	<.001	.004	3	2
BLOOD_Leukemia	NUP58 →	+0.617	+3.351	.005	.003	3	2
BLOOD_Leukemia	MTMR6 →	+0.676	+3.351	.003	.003	3	2
BLOOD_Leukemia	ZNF48 →	+0.758	+3.351	<.001	.003	3	2
UPPER_AERODIGESTIVE_TRACT	TFAP2D →	+0.116	+4.736	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 381 associations by consensus.

Exploration

SYNGAP1 survival (RNA) · tumor vs normal (RNA) · all SYNGAP1 data types