SYNE4

Across TCGA patient cohorts, SYNE4 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,057 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible SYNE4-associated proteins across cancer lineages are PPM1F, FAM83B_S869, and KRT6A. Each is linked with SYNE4 in more than 4 cancer types. Because this analysis shows association rather than direction, both SYNE4-to-partner and partner-to-SYNE4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SYNE4 versus PPM1F in UCEC, with a Pearson correlation of -0.30.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNE4→partner) and Y-score (partner→SYNE4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PPM1F →	-0.281	-0.534	.006	.005	3	5
LUAD	FAM83B_S869 →	-1.308	-0.718	.001	.004	3	4
LUAD	KRT6A →	-1.212	-0.433	<.001	.004	3	4
LSCC	KRT6A_S37 →	-1.565	-0.748	.001	.002	3	4
CCRCC	RBM15B_S109 →	+0.465	+0.509	<.001	<.001	3	4
HNSC	PAFAH1B3 →	+0.354	+0.688	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,057 associations by consensus.

SYNE4 vs PPM1F — UCEC

Explore this scatter interactively →