SYNE4

Across TCGA patient cohorts, SYNE4 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYNE4-associated genes across cancer lineages are AMPK_alpha, MSH6, and MSH2. Each is linked with SYNE4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SYNE4-to-partner and partner-to-SYNE4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AMPK_alpha grouped by SYNE4-low versus SYNE4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNE4→partner) and Y-score (partner→SYNE4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AMPK_alpha →	+0.245	+3.169	.019	.020	3	1
UCEC	MSH6 →	-0.515	-3.169	.004	.020	2	1
UCEC	MSH2 →	-0.426	-3.169	<.001	.020	1	1
UCEC	p62 Lck ligand →	+0.461	+3.169	.009	.020	1	1
UCEC	C-Raf_pS338 →	-0.088	-3.169	.049	.020	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

AMPK_alpha by SYNE4 expression — UCEC

Explore this box plot interactively →