SYNE3

Across TCGA patient cohorts, SYNE3 mutation is significantly associated with the RNA expression of many other genes, with 4,035 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYNE3-associated genes across cancer lineages are RPS29P32, ZNF92P1Y, and MRPS36P2. Each is linked with SYNE3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SYNE3-to-partner and partner-to-SYNE3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPS29P32 grouped by SYNE3-low versus SYNE3-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNE3→partner) and Y-score (partner→SYNE3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RPS29P32 →	+0.313	+4.649	<.001	.004	3	3
LUAD	ZNF92P1Y →	+0.006	+4.535	<.001	.002	3	3
STAD	MRPS36P2 →	+0.451	+2.718	.001	.004	3	3
COAD	TVP23B →	+0.398	+2.605	.007	.005	3	3
KIRP	SRIP1 →	+0.219	+5.770	<.001	.003	3	3
COAD	TAF13 →	+0.447	+2.013	.007	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,035 associations by consensus.

RPS29P32 by SYNE3 expression — BRCA

Explore this box plot interactively →