SYNE3

Across TCGA patient cohorts, SYNE3 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYNE3-associated genes across cancer lineages are MEK1, EGFR_pY1068, and ACC_pS79. Each is linked with SYNE3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SYNE3-to-partner and partner-to-SYNE3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by SYNE3-low versus SYNE3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNE3→partner) and Y-score (partner→SYNE3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.395	+3.169	<.001	<.001	3	3
UCEC	EGFR_pY1068 →	-0.214	-1.362	.008	.034	3	3
COAD	ACC_pS79 →	-0.294	-3.000	.012	.034	3	2
COAD	14-3-3_epsilon →	+0.155	+3.017	.002	.017	3	2
COAD	PKC-a_pS657 →	-0.265	-2.982	.029	.034	3	2
COAD	Src →	-0.162	-2.309	.034	.033	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

MEK1 by SYNE3 expression — UCEC

Explore this box plot interactively →