SYNE3

Across TCGA cell cohorts, SYNE3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,696 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible SYNE3-associated GO terms across cancer lineages are Positive regulation of fibroblast proliferation, Positive regulation of focal adhesion assembly, and Positive regulation of cell-substrate junction organization. Each is linked with SYNE3 in more than 11 cancer types. Because this analysis shows association rather than direction, both SYNE3-to-partner and partner-to-SYNE3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of fibroblast proliferation grouped by SYNE3-low versus SYNE3-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNE3→partner) and Y-score (partner→SYNE3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Positive regulation of fibroblast proliferation →	+0.110	+0.680	.001	.003	3	12
BONE	Positive regulation of focal adhesion assembly →	+0.153	+0.986	.007	.003	2	12
SKIN	Positive regulation of cell-substrate junction organization →	+0.096	+1.380	<.001	<.001	3	11
SKIN	Xenobiotic transport →	-0.087	-1.023	<.001	<.001	3	10
LUNG_NSCLC_LUSC	Regulation of metaphase plate congression →	+0.131	+1.091	<.001	<.001	3	9
PANCREAS	Negative regulation of small GTPase mediated signal transduction →	+0.074	+0.670	.002	.009	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,696 associations by consensus.

Positive regulation of fibroblast proliferation by SYNE3 expression — LUNG_NSCLC_LUAD

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