SYNE3

Across TCGA cell cohorts, SYNE3 mutation is significantly associated with the RNA expression of many other genes, with 377 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SYNE3-associated genes across cancer lineages are COL6A5, GPR3, and OR4X2. Each is linked with SYNE3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SYNE3-to-partner and partner-to-SYNE3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COL6A5 grouped by SYNE3-low versus SYNE3-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNE3→partner) and Y-score (partner→SYNE3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	COL6A5 →	+0.038	+2.760	<.001	.003	3	2
LARGE_INTESTINE	GPR3 →	+0.902	+3.364	<.001	.002	3	2
SOFT_TISSUE	OR4X2 →	+0.018	+5.369	.001	.004	3	1
SOFT_TISSUE	KRTAP17-1 →	+0.016	+5.369	<.001	.004	3	1
SOFT_TISSUE	SPANXN4 →	+0.946	+4.930	<.001	.008	3	1
SOFT_TISSUE	MROH5 →	+0.021	+4.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 377 associations by consensus.

COL6A5 by SYNE3 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →