SYNE2

Across TCGA cell cohorts, SYNE2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,782 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SYNE2-associated GO terms across cancer lineages are Actin filament-based transport, Nuclear migration, and Negative regulation of Arp2/3 complex-mediated actin nucleation. Each is linked with SYNE2 in more than 16 cancer types. Because this analysis shows association rather than direction, both SYNE2-to-partner and partner-to-SYNE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Actin filament-based transport grouped by SYNE2-low versus SYNE2-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNE2→partner) and Y-score (partner→SYNE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Actin filament-based transport →	+0.198	+1.915	<.001	.002	3	17
PANCREAS	Nuclear migration →	+0.120	+0.967	<.001	<.001	3	15
KIDNEY	Negative regulation of Arp2/3 complex-mediated actin nucleation →	+0.169	+1.172	.007	.009	3	13
LUNG_NSCLC_LUSC	Centrosome localization →	+0.120	+1.172	.002	.004	3	12
LUNG_NSCLC_LUSC	Microtubule organizing center localization →	+0.120	+1.172	.002	.004	3	12
PANCREAS	Nucleus localization →	+0.101	+1.106	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,782 associations by consensus.

Actin filament-based transport by SYNE2 expression — URINARY_TRACT

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