SYNE2

Across TCGA cell cohorts, SYNE2 mutation is significantly associated with the RNA expression of many other genes, with 3,016 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SYNE2-associated genes across cancer lineages are ACBD5, PSMB5, and P4HA1. Each is linked with SYNE2 in more than 4 cancer types. Because this analysis shows association rather than direction, both SYNE2-to-partner and partner-to-SYNE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACBD5 grouped by SYNE2-low versus SYNE2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNE2→partner) and Y-score (partner→SYNE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ACBD5 →	+0.720	+2.321	<.001	<.001	3	5
LARGE_INTESTINE	PSMB5 →	+0.414	+2.700	<.001	<.001	3	4
LARGE_INTESTINE	P4HA1 →	+0.754	+2.906	<.001	<.001	3	4
LARGE_INTESTINE	TBC1D14 →	+0.498	+1.678	.005	.002	3	4
LARGE_INTESTINE	FCHSD2 →	+0.553	+2.115	<.001	.001	3	4
LARGE_INTESTINE	PIP4K2A →	+0.516	+1.807	.007	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,016 associations by consensus.

ACBD5 by SYNE2 expression — LARGE_INTESTINE

Explore this box plot interactively →