SYNE1

Across TCGA pan-cancer cohorts, SYNE1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SYNE1 data layer compared with 24 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher SYNE1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated SYNE1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and CCRCC show a favorable association.

LUAD, CCRCC, and UCEC are the cancer types where SYNE1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	II,III,IV	0.830	0.420	.007	18	view →
CCRCC	DFS	Tertile	III,IV	0.810	0.429	.012	14	view →
UCEC	DFS	Quartile	II,III,IV	0.509	1.000	.021	8	view →
GBM	DFS	Tertile	All	0.816	0.644	.013	2	view →
LSCC	OS	Quartile	II,III,IV	0.706	1.000	.046	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SYNE1–LUAD (OS)

Open the LUAD breakdown →