SYNE1

Across TCGA patient cohorts, SYNE1 mutation is significantly associated with the total protein of many other genes, with 110 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYNE1-associated genes across cancer lineages are FoxM1, MYH11, and TFRC. Each is linked with SYNE1 in more than 6 cancer types. Because this analysis shows association rather than direction, both SYNE1-to-partner and partner-to-SYNE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by SYNE1-low versus SYNE1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNE1→partner) and Y-score (partner→SYNE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	FoxM1 →	+0.145	+1.068	.007	.007	3	7
READ	MYH11 →	-0.961	-1.502	.047	.019	3	7
LUAD	TFRC →	+0.415	+2.087	.001	.004	3	6
BLCA	Annexin_VII →	-0.106	-1.050	.001	.016	3	6
UCEC	Cyclin-B1 →	+0.454	+0.954	<.001	<.001	3	6
STAD	AMPK_alpha →	-0.126	-1.000	<.001	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 110 associations by consensus.

FoxM1 by SYNE1 expression — LUSC

Explore this box plot interactively →