SYNE1

Across TCGA cell cohorts, SYNE1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,934 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SYNE1-associated GO terms across cancer lineages are Regulation of stress-activated MAPK cascade, Positive regulation of focal adhesion assembly, and Positive regulation of cell-substrate junction organization. Each is linked with SYNE1 in more than 10 cancer types. Because this analysis shows association rather than direction, both SYNE1-to-partner and partner-to-SYNE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of stress-activated MAPK cascade grouped by SYNE1-low versus SYNE1-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNE1→partner) and Y-score (partner→SYNE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Regulation of stress-activated MAPK cascade →	+0.130	+1.813	.001	.001	3	11
OVARY	Positive regulation of focal adhesion assembly →	+0.128	+2.123	<.001	<.001	3	11
STOMACH	Positive regulation of cell-substrate junction organization →	+0.107	+1.648	.004	.004	3	11
UPPER_AERODIGESTIVE_TRACT	Macroautophagy →	+0.079	+1.508	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Golgi vesicle transport →	+0.078	+1.322	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Positive regulation of pinocytosis →	+0.132	+1.238	<.001	.003	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,934 associations by consensus.

Regulation of stress-activated MAPK cascade by SYNE1 expression — OESOPHAGUS

Explore this box plot interactively →