SYNE1

Across TCGA cell cohorts, SYNE1 mutation is significantly associated with the RNA expression of many other genes, with 1,971 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SYNE1-associated genes across cancer lineages are PGAP1, MDK, and FBXL4. Each is linked with SYNE1 in more than 4 cancer types. Because this analysis shows association rather than direction, both SYNE1-to-partner and partner-to-SYNE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PGAP1 grouped by SYNE1-low versus SYNE1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNE1→partner) and Y-score (partner→SYNE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PGAP1 →	+0.719	+3.321	<.001	.002	3	5
LARGE_INTESTINE	MDK →	-1.755	-1.078	.002	.004	3	4
LARGE_INTESTINE	FBXL4 →	+0.417	+0.943	.001	<.001	3	4
LARGE_INTESTINE	DTWD2 →	+0.481	+1.192	.004	.002	3	4
SKIN	CEP85L →	+0.637	+1.808	<.001	.001	3	4
BLOOD_Leukemia	GDPD1 →	+0.689	+1.968	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,971 associations by consensus.

PGAP1 by SYNE1 expression — SKIN

Explore this box plot interactively →