SYNCRIP

Across TCGA patient cohorts, SYNCRIP protein abundance is significantly associated with the protein abundance of many other proteins, with 36,316 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible SYNCRIP-associated proteins across cancer lineages are PRPF19, PRPF3, and PRPF4. Each is linked with SYNCRIP in more than 9 cancer types. Because this analysis shows association rather than direction, both SYNCRIP-to-partner and partner-to-SYNCRIP results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SYNCRIP versus PRPF19 in UCEC, with a Pearson correlation of 0.71.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNCRIP→partner) and Y-score (partner→SYNCRIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRPF19 →	+0.306	+0.244	<.001	<.001	3	10
LSCC	PRPF3 →	+0.345	+0.252	<.001	<.001	3	10
LSCC	PRPF4 →	+0.306	+0.286	<.001	<.001	3	10
UCEC	CPSF2 →	+0.231	+0.263	<.001	<.001	3	10
UCEC	CPSF3 →	+0.233	+0.252	<.001	<.001	3	10
LSCC	DDX23 →	+0.307	+0.307	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 36,316 associations by consensus.

SYNCRIP vs PRPF19 — UCEC

Explore this scatter interactively →