SYNCRIP

Across TCGA patient cohorts, SYNCRIP mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYNCRIP-associated genes across cancer lineages are ATM, 14-3-3_beta, and EGFR_pY1068. Each is linked with SYNCRIP in more than 2 cancer types. Because this analysis shows association rather than direction, both SYNCRIP-to-partner and partner-to-SYNCRIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by SYNCRIP-low versus SYNCRIP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNCRIP→partner) and Y-score (partner→SYNCRIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.619	-3.893	<.001	<.001	3	3
UCEC	14-3-3_beta →	-0.076	-2.195	.022	.009	3	1
UCEC	EGFR_pY1068 →	-0.164	-1.392	.047	.019	3	1
UCEC	eIF4E →	+0.154	+2.321	.026	.005	3	1
UCEC	Heregulin →	-0.091	-1.678	.026	.021	3	1
UCEC	INPP4B →	-0.238	-2.321	.025	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

ATM by SYNCRIP expression — UCEC

Explore this box plot interactively →