SYNCRIP

Across TCGA cell cohorts, SYNCRIP mutation is significantly associated with the RNA expression of many other genes, with 222 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SYNCRIP-associated genes across cancer lineages are CBY1, IFT27, and INTS10. Each is linked with SYNCRIP in more than 1 cancer types. Because this analysis shows association rather than direction, both SYNCRIP-to-partner and partner-to-SYNCRIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CBY1 grouped by SYNCRIP-low versus SYNCRIP-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNCRIP→partner) and Y-score (partner→SYNCRIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CBY1 →	+0.683	+3.160	<.001	.006	3	1
LARGE_INTESTINE	IFT27 →	+0.852	+3.299	.003	.004	3	1
LARGE_INTESTINE	INTS10 →	+0.641	+3.212	.006	.006	3	1
LARGE_INTESTINE	MED26 →	+0.359	+3.212	.001	.006	3	1
LARGE_INTESTINE	HIPK3 →	+0.573	+3.212	.004	.006	3	1
LARGE_INTESTINE	RIC8B →	+0.497	+3.212	.007	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 222 associations by consensus.

CBY1 by SYNCRIP expression — LARGE_INTESTINE

Explore this box plot interactively →