SYNC

Across TCGA patient cohorts, SYNC protein abundance is significantly associated with the RNA expression of many other genes, with 15,945 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SYNC-associated genes across cancer lineages are MYLK, CXCL12, and PMP22. Each is linked with SYNC in more than 8 cancer types. Because this analysis shows association rather than direction, both SYNC-to-partner and partner-to-SYNC results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SYNC versus MYLK in OV, with a Pearson correlation of 0.38.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNC→partner) and Y-score (partner→SYNC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	MYLK →	+1.264	+0.455	.001	.001	3	9
BRCA	CXCL12 →	+1.252	+0.690	<.001	<.001	3	8
OV	PMP22 →	+0.854	+0.461	.008	.002	3	8
BRCA	SPARC →	+1.473	+0.659	<.001	<.001	3	8
OV	CALD1 →	+0.975	+0.417	.006	.003	3	8
COAD	CNN1 →	+2.223	+0.825	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,945 associations by consensus.

SYNC vs MYLK — OV

Explore this scatter interactively →