SYNC

Across TCGA patient cohorts, SYNC mutation is significantly associated with the RNA expression of many other genes, with 1,395 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYNC-associated genes across cancer lineages are NPLP1, SCAND3P1, and RNU6-1155P. Each is linked with SYNC in more than 1 cancer types. Because this analysis shows association rather than direction, both SYNC-to-partner and partner-to-SYNC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPLP1 grouped by SYNC-low versus SYNC-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNC→partner) and Y-score (partner→SYNC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	NPLP1 →	+0.291	+5.421	<.001	.005	3	2
COAD	SCAND3P1 →	+0.282	+5.080	<.001	.008	3	2
UCEC	RNU6-1155P →	+0.099	+4.153	.007	.005	3	2
UCEC	RNU6-1067P →	+0.243	+2.190	.003	.009	3	2
UCEC	MTATP6P21 →	+0.299	+2.092	<.001	.007	3	2
UCEC	RPL35AP3 →	+0.226	+2.156	.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,395 associations by consensus.

NPLP1 by SYNC expression — READ

Explore this box plot interactively →