SYNC

Across TCGA patient cohorts, SYNC mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYNC-associated genes across cancer lineages are MEK1, 14-3-3_beta, and eIF4E. Each is linked with SYNC in more than 1 cancer types. Because this analysis shows association rather than direction, both SYNC-to-partner and partner-to-SYNC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by SYNC-low versus SYNC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNC→partner) and Y-score (partner→SYNC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.481	+3.321	.008	.010	3	2
UCEC	14-3-3_beta →	-0.107	-2.308	.033	.036	3	1
UCEC	eIF4E →	+0.210	+2.321	.047	.035	3	1
UCEC	ACC_pS79 →	+0.395	+2.321	.023	.035	3	1
UCEC	ACC1 →	+0.491	+2.321	.007	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.206	-3.169	.015	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

MEK1 by SYNC expression — UCEC

Explore this box plot interactively →