SYNC

Across TCGA cell cohorts, SYNC mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SYNC-associated genes across cancer lineages are OR1E3, TBC1D21, and PFN3. Each is linked with SYNC in more than 1 cancer types. Because this analysis shows association rather than direction, both SYNC-to-partner and partner-to-SYNC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1E3 grouped by SYNC-low versus SYNC-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNC→partner) and Y-score (partner→SYNC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	OR1E3 →	+0.187	+4.285	<.001	.007	3	1
LARGE_INTESTINE	TBC1D21 →	+0.015	+5.022	<.001	.002	3	1
LARGE_INTESTINE	PFN3 →	+0.169	+4.467	<.001	.004	3	1
LARGE_INTESTINE	PYDC2 →	+0.108	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

OR1E3 by SYNC expression — STOMACH

Explore this box plot interactively →